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Tau proteins in the brains of people with Alzheimer’s disease are misfolded and abnormally shaped. Plaque, deposits of a toxic protein called beta-amyloid in the spaces between nerve cells in the brain; and tangles, knotted threads of the tau protein found within brain cells, are considered the key indicators of Alzheimer’s. AADvac1 is a vaccine that stimulates the body’s immune system to attack the abnormal form of tau protein that causes the internal skeleton of neurons to fall apart. If successful, it has the potential to help stop the progression of Alzheimer’s disease.
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